ScienceDaily
Scientists inject one tumor and watch cancer vanish across the body
Researchers have developed a more potent CD40 agonist antibody that, when injected directly into a single tumor, triggers a systemic immune response capable of attacking cancer throughout the body. In a small trial of 12 metastatic cancer patients, half saw tumor shrinkage and two achieved complete remission. The localized delivery approach sidesteps the toxic side effects that derailed earlier versions of the therapy, potentially reviving a long-stalled class of cancer treatments.
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Scientists finally reveal how this Alzheimer’s drug really works
Lecanemab, one of the first drugs approved to slow Alzheimer's progression, clears harmful amyloid plaques by activating microglia — the brain's immune cells — through a specific antibody fragment called the Fc region. Until now, the precise mechanism behind the drug's effect had remained poorly understood. The discovery gives researchers a concrete molecular target to optimize, potentially accelerating the development of more effective next-generation treatments.
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Rare supernova from 10 billion years ago may reveal the secret of dark energy
Gravitational lensing has given astronomers an unprecedented window into the early universe, with the discovery of a supernova whose light — bent around a foreground galaxy — arrived on Earth in multiple copies at different times. That time delay effectively allows scientists to replay the explosion in slow motion, observing distinct moments in its history from a single event 10 billion years in the past. The finding could sharpen our understanding of dark energy by offering a rare, independent method for measuring the universe's expansion rate.
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