Phys.org
Nanoparticles sneak antibodies into cells to inhibit cancer and inflammation
Researchers have developed a lipid nanoparticle delivery system capable of smuggling therapeutic antibodies directly into cells — a significant technical hurdle that has long limited antibody-based treatments. The approach opens the door to targeting intracellular proteins involved in cancer and inflammatory disease, which were previously out of reach for conventional antibody therapies. If the method translates clinically, it could dramatically expand the therapeutic applications of one of medicine's most powerful drug classes.
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New algorithm identifies disease-linked changes in cells without prior training
Researchers at the University of Waterloo have developed RNovA, a machine-learning algorithm capable of identifying disease-linked protein changes in human cells without requiring prior training data. Published in Nature Biotechnology, the tool could accelerate research into cancer, Alzheimer's, and other life-threatening conditions. Its ability to operate without pre-labeled datasets makes it a potentially powerful tool for uncovering biological signals that existing methods might miss.
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Self-driving chemistry lab discovers catalysts that can switch products on demand
Researchers have built an autonomous laboratory that independently tests hundreds of catalyst combinations to find faster, more selective chemical reactions — without human intervention. The system can identify catalysts capable of switching their output products on command, a rare and valuable property for industrial manufacturing. The breakthrough could dramatically compress the timeline for developing new catalysts across pharmaceuticals, plastics, and fuel production.
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Drug peptides defy shape rules, activating receptors without full spiral form
Peptide drugs have long been assumed to require a specific helical shape to activate cell receptors, but new research from the Gellman Group at UW–Madison challenges that assumption. Their findings show that certain drug peptides can trigger receptor responses without adopting the complete spiral structure previously considered essential. This discovery could reshape how researchers design peptide-based therapeutics, potentially opening doors to more effective and flexible drug candidates.
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